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Interactive Effects of Physical Activity and APOE-ε4 on BOLD Semantic Memory Activation in Healthy Eldersled Post

posted Nov 8, 2010, 2:08 PM by Karen Outzen   [ updated Nov 20, 2010, 1:49 PM by Erin Browning ]

Evidence suggests that physical activity (PA) is associated with the maintenance of cognitive function across the
lifespan. In contrast, the apolipoproteinE-ε4 (APOE-ε4) allele, a genetic risk factor for Alzheimer's disease (AD), is
associated with impaired cognitive function. The objective of this study was to examine the interactive effects of
PA and APOE-ε4 on brain activation during memory processing in older (ages 65–85) cognitively intact adults.
© 2010 Elsevier Inc. All rights reserved.

Erin Browning,
Nov 8, 2010, 2:14 PM